---
title: "GLP-1 Receptor Agonists in Sleep Medicine: Pan-European Practice Patterns and Unmet Needs"
id: "pubmed-42639925"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42639925"
content_type: "clinical_feed_article"
specialty: "Pulmonology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42639925/"
doi: "10.1080/25310429.2026.2722795"
published_at: "2026-08-25T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# GLP-1 Receptor Agonists in Sleep Medicine: Pan-European Practice Patterns and Unmet Needs
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42639925
- **Specialty:** [Pulmonology](https://medichelpline.com/clinical-feed/pulmonology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42639925/)
- **DOI:** [10.1080/25310429.2026.2722795](https://doi.org/10.1080%2F25310429.2026.2722795)
- **Published At:** 2026-08-25T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- A pan-European survey by the European Sleep Apnoea Database (ESADA) network examined real-world integration of **GLP-1 receptor agonists (GLP-1RAs)** and dual GIP/GLP-1 agonists in sleep clinics for patients with obesity and suspected or established **obstructive sleep apnoea (OSA)**. - The survey included 24 centres across 14 European countries and captured current diagnostic, treatment-initiation, monitoring, and follow-up practices. - Forty-two percent of centres reported that **sleep physicians** can initiate GLP-1RA therapy directly within the sleep clinic setting. - Indications for GLP-1RA use were consistent across centres, primarily targeting moderate-to-severe obesity with metabolic comorbidities. - Most centres continued to recommend diagnostic sleep studies after GLP-1RA initiation: 92% for symptomatic patients and 81% for asymptomatic patients. - A weight loss threshold greater than 10% was viewed as a clinically meaningful trigger for OSA reassessment by 61% of centres. - Despite expectations of reduced OSA severity with GLP-1RA–associated weight loss, only 14% of centres reported proactive **positive airway pressure (PAP)** re-titration or withdrawal. - Monitoring practices emphasized weight trajectory, patient symptoms, and PAP telemonitoring; structured interdisciplinary pathways were largely absent. - The study concluded that while GLP-1RAs are increasingly incorporated into European sleep practice, substantial variability exists in diagnostic timing, PAP management, and follow-up strategies, highlighting the need for harmonized guidance and coordinated multidisciplinary care.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 25. # Clinical practice patterns and unmet needs in the use of GLP-1 receptor agonists in sleep medicine: A pan-European survey performed in the European sleep apnoea database network [Dries Testelmans](https://pubmed.ncbi.nlm.nih.gov/?term=Testelmans+D&cauthor_id=42639925)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-1 "Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium."), [Maria Rosaria Bonsignore](https://pubmed.ncbi.nlm.nih.gov/?term=Bonsignore+MR&cauthor_id=42639925)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-2 "PROMISE Department, University of Palermo, Palermo, Italy."), [Athanasia Pataka](https://pubmed.ncbi.nlm.nih.gov/?term=Pataka+A&cauthor_id=42639925)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-3 "Respiratory Failure Unit, G. Papanikolaou Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece."), [Francesco Fanfulla](https://pubmed.ncbi.nlm.nih.gov/?term=Fanfulla+F&cauthor_id=42639925)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-4 "Istituti Clinici Scientifici Maugeri Istituto Scientifico di Pavia e Montescano IRCCS, Unità Operativa di Fisiopatologia Respiratoria e Medicina del Sonno, Pavia, Italy."), [Silke Ryan](https://pubmed.ncbi.nlm.nih.gov/?term=Ryan+S&cauthor_id=42639925)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-5 "Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland."), [Carolina Lombardi](https://pubmed.ncbi.nlm.nih.gov/?term=Lombardi+C&cauthor_id=42639925)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-6 "Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan & Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."), [Winfried Randerath](https://pubmed.ncbi.nlm.nih.gov/?term=Randerath+W&cauthor_id=42639925)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-7 "Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany."), [Ludger Grote](https://pubmed.ncbi.nlm.nih.gov/?term=Grote+L&cauthor_id=42639925)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-8 "Centre for Sleep and Wake Disorders, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden."), [Alexandros Kalkanis](https://pubmed.ncbi.nlm.nih.gov/?term=Kalkanis+A&cauthor_id=42639925)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#full-view-affiliation-1 "Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium.") Affiliations Expand ### Affiliations * 1 Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium. * 2 PROMISE Department, University of Palermo, Palermo, Italy. * 3 Respiratory Failure Unit, G. Papanikolaou Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. * 4 Istituti Clinici Scientifici Maugeri Istituto Scientifico di Pavia e Montescano IRCCS, Unità Operativa di Fisiopatologia Respiratoria e Medicina del Sonno, Pavia, Italy. * 5 Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland. * 6 Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan & Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. * 7 Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany. * 8 Centre for Sleep and Wake Disorders, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. * PMID: **42639925** * DOI: [ 10.1080/25310429.2026.2722795 ](https://doi.org/10.1080/25310429.2026.2722795) Item in Clipboard Multicenter Study # Clinical practice patterns and unmet needs in the use of GLP-1 receptor agonists in sleep medicine: A pan-European survey performed in the European sleep apnoea database network Dries Testelmans et al. Pulmonology. 2026 Dec. Show details Display options Display options Format Abstract PubMed PMID Pulmonology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Pulmonology%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Pulmonology%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42639925/) . 2026 Dec;32(1):2722795. doi: 10.1080/25310429.2026.2722795. Epub 2026 Aug 25. ### Authors [Dries Testelmans](https://pubmed.ncbi.nlm.nih.gov/?term=Testelmans+D&cauthor_id=42639925)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-1 "Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium."), [Maria Rosaria Bonsignore](https://pubmed.ncbi.nlm.nih.gov/?term=Bonsignore+MR&cauthor_id=42639925)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-2 "PROMISE Department, University of Palermo, Palermo, Italy."), [Athanasia Pataka](https://pubmed.ncbi.nlm.nih.gov/?term=Pataka+A&cauthor_id=42639925)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-3 "Respiratory Failure Unit, G. Papanikolaou Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece."), [Francesco Fanfulla](https://pubmed.ncbi.nlm.nih.gov/?term=Fanfulla+F&cauthor_id=42639925)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-4 "Istituti Clinici Scientifici Maugeri Istituto Scientifico di Pavia e Montescano IRCCS, Unità Operativa di Fisiopatologia Respiratoria e Medicina del Sonno, Pavia, Italy."), [Silke Ryan](https://pubmed.ncbi.nlm.nih.gov/?term=Ryan+S&cauthor_id=42639925)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-5 "Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland."), [Carolina Lombardi](https://pubmed.ncbi.nlm.nih.gov/?term=Lombardi+C&cauthor_id=42639925)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-6 "Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan & Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy."), [Winfried Randerath](https://pubmed.ncbi.nlm.nih.gov/?term=Randerath+W&cauthor_id=42639925)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-7 "Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany."), [Ludger Grote](https://pubmed.ncbi.nlm.nih.gov/?term=Grote+L&cauthor_id=42639925)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-8 "Centre for Sleep and Wake Disorders, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden."), [Alexandros Kalkanis](https://pubmed.ncbi.nlm.nih.gov/?term=Kalkanis+A&cauthor_id=42639925)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42639925/#short-view-affiliation-1 "Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium.") ### Affiliations * 1 Department of Pulmonology, University Hospitals Leuven, Leuven, Belgium. * 2 PROMISE Department, University of Palermo, Palermo, Italy. * 3 Respiratory Failure Unit, G. Papanikolaou Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. * 4 Istituti Clinici Scientifici Maugeri Istituto Scientifico di Pavia e Montescano IRCCS, Unità Operativa di Fisiopatologia Respiratoria e Medicina del Sonno, Pavia, Italy. * 5 Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin, Ireland. * 6 Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, St. Luke Hospital, Milan & Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. * 7 Clinic of Pneumology and Allergology, Center for Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany. * 8 Centre for Sleep and Wake Disorders, Institute of Medicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden. * PMID: **42639925** * DOI: [ 10.1080/25310429.2026.2722795 ](https://doi.org/10.1080/25310429.2026.2722795) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GIP/GLP-1 agonists have demonstrated weight loss benefits and reductions in obstructive sleep apnoea (OSA) severity. Following recent regulatory approval of tirzepatide for OSA with obesity, their integration into sleep medicine is accelerating. However, real-world clinical practice remains undefined. **Methods:** The European Sleep Apnoea Database (ESADA) network conducted a multinational online survey across 24 centres in 14 European countries to evaluate current practice patterns regarding GLP-1RA use in patients with obesity and suspected or established OSA. **Results:** Forty-two percent of centres reported that GLP-1RA therapy could be initiated by sleep physicians within the sleep clinic. Indications were consistent, primarily targeting moderate-to-severe obesity with metabolic comorbidities. Most clinicians continued to recommend diagnostic sleep studies in symptomatic (92%) and asymptomatic (81%) patients recently started on GLP-1RAs. A weight loss threshold > 10% was considered clinically meaningful for OSA reassessment by 61% of centres. Despite anticipated reductions in OSA severity, proactive positive airway pressure (PAP) re-titration or withdrawal was uncommon (14%). Monitoring focused on weight trajectory, symptoms, and PAP telemonitoring. Structured interdisciplinary pathways were largely absent. **Conclusions:** GLP-1RAs are increasingly incorporated into European sleep practice; however, substantial variability exists in diagnostic timing, PAP management, and follow-up strategies. Harmonised guidance and coordinated multidisciplinary care are urgently needed. **Keywords:** GLP-1 receptor agonists; Obstructive sleep apnoea; clinical practice survey; obesity; positive airway pressure. 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