---
title: "Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia"
id: "plos-one-5-comparative-clinical-outcomes-of-polymyxin-based-versus-non-polymyxin-regimens"
canonical_url: "https://medichelpline.com/clinical-feed/plos-one-5-comparative-clinical-outcomes-of-polymyxin-based-versus-non-polymyxin-regimens"
content_type: "clinical_feed_article"
specialty: "Research Highlights"
source_name: "PLOS ONE (Medicine)"
source_url: "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353799"
published_at: "2026-07-15T14:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/plos-one-5-comparative-clinical-outcomes-of-polymyxin-based-versus-non-polymyxin-regimens
- **Specialty:** [Research Highlights](https://medichelpline.com/clinical-feed/research-highlights.md)
- **Primary Source:** PLOS ONE (Medicine)
- **Source URL:** [Original Journal Publication](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353799)
- **Published At:** 2026-07-15T14:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
by Divya Bhat, Asha K. Rajan, Vandana Kalwaje Eshwara, Muralidhar Varma, Shashikiran Umakanth, Girish Thunga, Vishal Shanbhag Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteraemia poses a major therapeutic challenge due to limited effective therapeutic options and high mortality. Although polymyxins remain widely used, emerging evidence suggests that non-polymyxin regimens may offer improved efficacy and safety. This study compared clinical and microbiological outcomes between polymyxin-based therapy (PBT) and non-polymyxin regimens (NPR) in patients with CRKP bloodstream infections (BSI). Methods In this multicentric, retrospective observational study, adult patients (≥18 years) with confirmed CRKP bacteraemia admitted between January 2019 and December 2023 were included. Patients were categorised based on definitive therapy as PBT or NPR. Baseline characteristics, disease severity, and outcomes were compared using appropriate statistical tests. Predictors of in-hospital mortality were identified by multivariable Cox regression, validated by bootstrap resampling, and assessed through landmark sensitivity analysis excluding early deaths ( Results Of 1,009 patients with K. pneumoniae bacteraemia, 244 patients with CRKP met inclusion criteria (PBT, n = 143; NPR, n = 101).
## Clinical Analysis & Structured Key Points
PLOS ONE (Medicine) published a clinical update in Research Highlights on 15 Jul 2026. The item focuses on Comparative clinical outcomes of polymyxin-based versus non-polymyxin regimens as definitive therapy in Carbapenem-resistant Klebsiella pneumoniae bacteraemia. Review the original article for the full source wording and details.
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