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The authors extend **sensitivity-based conservation prioritization** to quantify where local habitat change most strongly affects landscape-scale connectivity relevant to persistence. - They derive sp...
The study assessed **guide RNA (gRNA) truncation** as a strategy to modulate nucleotide-level outcomes of **base editing**, using ABE8e in HUDEP-2 cells and other contexts reported by the authors. - T...
The study applies **molecular editing** to repurpose an existing dual NSD2/GSPT1 degrader (LLC0424) into two structurally related compounds with distinct mechanisms: 424-ND and 424-GD. - 424-ND functi...
The authors developed a **high-throughput spheroid** assay to study cell death in patient-derived glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) models grown as spheroids. - They syste...
The study analyzed **single-cell** transcriptional responses of peripheral blood mononuclear cells from 12 donors exposed in vitro to 90 cytokine perturbations. - For a given donor and perturbation, r...
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The study used combined chloroplast ndhF-rpl32 and nuclear ITS sequences to perform molecular phylogenetic analyses on 30 Begonia species from Peninsular Malaysia, representing all regional sections a...
Mechanical signals are central regulators of plant cellular responses, guiding development and triggering defense and repair processes; however, plant mechanoperception mechanisms remain poorly unders...
The authors introduce a reaction-diffusion–inspired **activator-inhibitor cellular automaton** that functions as a tunable nonlinear medium for information processing rather than only pattern formatio...
The study maps how single-residue variation in the six-residue loop 2 (L2) of histone variants **H2A** and **H2A.Z** alters cellular function at single-residue resolution. - Genome-scale interaction m...
This preprint describes a study of **pollen germination** and pollen tube elongation in Douglas-fir (Pseudotsuga menziesii) across incubation temperatures from 5 to 40°C, using a convolutional neural...
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