Introduction The Ablative Technique Options for Preserving fertility in Endometrioma study is a prospective, monocentric clinical study that combines a randomised controlled trial comparing cystectomy and plasma vapourisation for endometriomas measuring between 2 cm and 6 cm with a parallel observational cohort evaluating sclerotherapy for endometriomas larger than 6 cm. The primary outcome is the cumulative pregnancy rate at 24 months.
Secondary outcomes include ovarian reserve, recurrence, complications and pain scores. Methods and analysis A total of 332 women with unilateral or bilateral ovarian endometriomas will be enrolled at Institut Franco-Européen de prise en charge multidisciplinaire de l'endométriose.
Women with an indication for deep endometriosis surgery and endometriomas 6 cm will be allocated to a prospective observational cohort undergoing laparoscopic sclerotherapy. The primary endpoint will be the cumulative pregnancy rate (spontaneous or assisted) at 24 months.
Secondary outcomes include live birth rates, spontaneous and assisted reproductive technology pregnancy rates, rate of ongoing pregnancies beyond 12 weeks' gestational age, recurrence rates and postoperative complications. Intention-to-treat and per-protocol analyses will be performed.
The trial centers on preserving fertility as a primary aim.
Location of recruitment is a single multidisciplinary center in France.
Both intention-to-treat and per-protocol analyses are planned.