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Effect of non-invasive preimplantation genetic testing for aneuploidies (ni-PGT) on cumulative ongoing pregnancy in infertile women of advanced maternal age: a multicentre, open-label, randomised controlled trial protocol
03 Jun 20265 min read0 viewsJournal Feed
GIST (Key Takeaways)
- Introduction Embryo aneuploidy increases substantially with maternal age, contributing to implantation failure and miscarriage. Conventional morphological assessment cannot determine euploidy.
- Non-invasive preimplantation genetic testing (ni-PGT) evaluates cell-free DNA in spent embryo culture medium, potentially improving embryo selection without trophectoderm biopsy. Robust evidence of clinical benefit in women aged 35 - 42 years remains limited.
- Methods and analysis This is a multicentre, open-label, parallel-group randomised controlled trial conducted in three centres in China. Infertile women aged 35 - 42 years undergoing their first intracytoplasmic sperm injection cycle and having ≥2 good-quality days 5 - 6 blastocysts (Gardner grade ≥4BC,defined as an expansion grade of at least 4, with an inner cell mass grade of B or better and a trophectoderm grade of C or better) will be randomised 1:1 to ni-PGT-guided embryo selection or conventional morphology-based selection.
- Randomisation will be stratified by study centre using variable permuted block sizes of 4 and 6 and implemented through a unified centralised randomisation system.
Clinical Editorial
Summary
BMJ Open published a clinical update in Research Highlights on 03 Jun 2026.
The item focuses on Effect of non-invasive preimplantation genetic testing for aneuploidies (ni-PGT) on cumulative ongoing pregnancy in infertile women of advanced maternal age: a multicentre, open-label, randomised controlled trial protocol.
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Feed Metadata
Source
BMJ Open
Category
Research Highlights
Published
03 Jun 2026
Feed Metadata
Source
BMJ Open
Category
Research Highlights
Published
03 Jun 2026