Background Persistent fatigue is a frequent symptom in chronic medical conditions. Systematic reviews of non-pharmacological interventions for fatigue have identified interventions that are effective at reducing fatigue, but there is limited published evidence on the cost-effectiveness of these interventions.
Objective To identify non-pharmacological fatigue interventions that have the potential to be cost-effective in patients with long-term medical conditions. Design Decision analytic modelling with intervention costs estimated from staff time and quality-of-life outcomes mapped from a systematic review and network meta-analysis of fatigue outcomes.
Setting UK National Health Service (NHS). Participants People with persistent fatigue associated with a chronic medical condition.
Interventions Non-pharmacological fatigue interventions versus usual care. Primary and secondary outcome measures Net monetary benefit from a UK NHS and Personal Social Services perspective; quality-adjusted life years (QALYs) gained; intervention costs valued at 2022/23 prices; costs and benefits discounted at 3.5% per annum.
BMJ Open published a clinical update in Research Highlights on 24 Apr 2026.
The item focuses on Model-based economic evaluation of non-pharmacological interventions for fatigue in patients with long-term medical conditions in the UK.
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