Purpose The BioCaPPE (Biomarkers of Prostate Cancer/Prevention and Environment) study is a multicentre prospective observational cohort designed to identify biomarkers associated with prostate cancer (PCa) risk that may be modifiable through lifestyle factors. This paper describes the cohort, along with the data and bio-samples available for future studies in PCa risk assessment.
Participants Canadian men at risk of PCa were enrolled based on one of two criteria (1) negative first prostate biopsy within 6 months from enrolment (Group 1); or (2) a prostate-specific antigen (PSA) blood level between 2.5 and 10 ng/mL without prior prostate biopsy (Group 2). At baseline, blood samples and comprehensive data were collected.
PCa incidence and lifestyle factors were updated for all participants over 2 years, with extended follow-up for those who provided additional consent. Findings to date Recruitment was conducted across four health centres in Quebec, Canada.
A total of 2053 men were enrolled - 1499 in Group 1 and 554 in Group 2.
BMJ Open published a clinical update in Research Highlights on 28 May 2026.
The item focuses on Cohort profile: BioCaPPE (Biomarkers of Prostate Cancer/Prevention and Environment) - a Canadian multicentre prospective study of lifestyle and candidate biomarkers in relation to prostate cancer risk.
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