Psychological predictors of adherence to antiretroviral therapy among people living with HIV in high-income countries: a systematic review protocol

Introduction People living with HIV (PLHIV) frequently face psychological challenges, including stigma, stress and social isolation, which can negatively affect adherence to antiretroviral therapy (ART). Even in high-income countries where treatment is accessible, poor adherence can lead to drug resistance, reduced immune function and early morbidity.

This systematic review aims to synthesise evidence on the relationship between psychological and mental health factors and ART adherence among PLHIV in high-income settings. Methods and analysis We will include studies published in any language between January 2015 and the date of the last searches.

Reports of studies published in languages other than English, and which appear to be eligible for inclusion after the first level of screening, will be translated using Google Translate. Studies will be included if they continue to meet the inclusion criteria and the quality of the translation is sufficient to extract the relevant data.

PLHIV aged ≥15 years receiving ART in high-income countries. The studies to be included must assess psychological or mental health variables and ART adherence.

Peer-reviewed journal articles will be the primary source of evidence.