Marco et al. demonstrate that radiotherapy epigenetically reprograms AAV episomes to enhance transgene expression.
They present an inducible AAV platform that allows tumor-restricted cytokine delivery. Intratumoral AAV-iIL12 injection following irradiation safely induces robust local and systemic antitumor immunity, revealing a synergy between radiotherapy and an AAV-based immunotherapy for cancer treatment.
Cancer Cell published a clinical update in Oncology on 23 Mar 2026. The item focuses on Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity. Open the detail page to review the full original feed content.