Zhang et al. present a comprehensive genomic and immunological analysis of the premalignant-to-malignant transition in hepatocellular carcinoma, showing TERT alterations predispose to malignancy, while copy number alterations (CNAs) account for the transition. They propose two major evolutionary scenarios, CNA-dominant progression and inflamed progression with immune evasion.
Cancer Cell published a clinical update in Oncology on 26 Mar 2026. The item focuses on Molecular insights into early malignant transition of hepatocellular carcinoma. Open the detail page to review the full original feed content.