Bolli et al. develop a classifier that rescues neutrophils typically lost in scRNA-seq data, enabling unified pan-cancer analyses.
This approach identifies CCL3hi aged tumor-associated neutrophils conserved across human and mouse cancers. Mechanistic perturbations show that neutrophil-derived CCL3 drives their CCR1-dependent survival in hypoxic niches, thereby promoting tumor progression.
Cancer Cell published a clinical update in Oncology on 05 Feb 2026.
The item focuses on CCL3 is produced by aged neutrophils across cancers and promotes tumor growth.
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