Greenhalgh et al. develop a resource of curated structural variants (SVs) from 1,616 pediatric cancer genomes for pan-cancer analyses and compared it with SVs from 2,203 adult cancers. Differences in target genes, recurrent hotspots, and SV signatures in these cohorts reveal varying mutagenesis mechanisms and their impact on tumorigenesis.
Cancer Cell published a clinical update in Oncology on 12 Mar 2026. The item focuses on The landscape of structural variation in pediatric cancer. Open the detail page to review the full original feed content.