Bandlamudi et al. analyze 54,331 tumors across 448 cancer subtypes to define cancer type-specific patterns of driver alterations. They identify 164 new cancer hotspots and show that driver clonality, zygosity, age of disease onset associations, and HLA-dependent immunogenicity vary by tissue context, refining biological interpretation and clinical actionability.
Cancer Cell published a clinical update in Oncology on 26 Mar 2026. The item focuses on Cancer type-specific variation in patterns of driver alterations across 50,000 tumors. Open the detail page to review the full original feed content.