Wang et al. show that chemotherapy reprograms liver-resident Kupffer cells into LEPR+ tumor-infiltrating cells that clear immunogenic cell death signals via MerTK-dependent efferocytosis. Targeting chemotherapy-induced LEPR+ Kupffer cells restores tumor immunogenicity and overcomes chemoresistance in liver metastases.
Cancer Cell published a clinical update in Oncology on 12 Feb 2026.
The item focuses on Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases.
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