Kirschstein et al. discover that TGFβ receptor signaling in myofibroblasts blocks the differentiation of reticular fibroblasts associated with TLS formation in murine PDAC.
Antagonizing TGFβR1 allows LTBR-dependent T and B cell recruitment and increases tumor control. This work demonstrates barriers to TLS formation in PDAC applicable to other immunotherapy-resistant solid tumors.
Cancer Cell published a clinical update in Oncology on 26 Mar 2026. The item focuses on Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer. Open the detail page to review the full original feed content.