How premalignant tissue transforms into cancer remains an open question. In this issue of Cancer Cell, Zhang et al. address this by comparing early hepatocellular carcinomas with matched premalignant tissue, revealing potential paths for malignant transformation: one characterized by high copy-number alteration burden and one characterized by high inflammation.
Cancer Cell published a clinical update in Oncology on 02 Apr 2026. The item focuses on A snapshot of the earliest stages of hepatocellular carcinoma. Open the detail page to review the full original feed content.