Clonal competition eliminates most early neoplastic lesions, yet a subset persists and ultimately progresses. In Nature, Skrupskelyte et al.
demonstrate that nascent tumors survive by actively reshaping a precancerous niche through epithelial-stromal feedback. This ecological gatekeeping mechanism reframes tumor initiation from a process of mutation accumulation to microenvironmental selection and co-evolution.
Cancer Cell published a clinical update in Oncology on 16 Apr 2026. The item focuses on Precancerous niches as gatekeepers of tumor initiation. Open the detail page to review the full original feed content.