Cancer cachexia is a tumor-driven collapse of systemic homeostasis rather than a passive consequence of advanced disease. In this review, Zhang et al.
define a tumor-centric framework in which tumor-derived signals rewire immune, metabolic, and neuroendocrine networks across organs, establishing self-sustaining catabolic feedback loops. This model provides a conceptual foundation for biomarker-guided and mechanism-based therapeutic strategies.
Cancer Cell published a clinical update in Oncology on 16 Apr 2026. The item focuses on Cancer cachexia: A tumor-driven disorder of whole-body homeostasis. Open the detail page to review the full original feed content.