Mateus-Tique et al. demonstrate that targeting FOLR2+ or TREM2+ tumor-associated macrophages with IL-12-expressing CAR-T cells eliminates immunosuppressive macrophages and unleashes endogenous anti-tumor immunity, leading to tumor clearance and improved survival in models of metastatic cancers.
Cancer Cell published a clinical update in Oncology on 22 Jan 2026.
The item focuses on Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth.
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