Shi et al. delineate an interplay among tumor cells, immune cells, and the nervous system that drives cancer cachexia and anorexia.
Specifically, tumor-derived CSF1 induces macrophage GDF15, which signals through the GFRAL-RET neural axis to enhance β-adrenergic activity and systemic wasting. Disrupting this feedforward loop alleviates cachexia across cancer models.
Cancer Cell published a clinical update in Oncology on 12 Feb 2026. The item focuses on Tumor-immune-neural circuit disrupts energy homeostasis in cancer cachexia. Open the detail page to review the full original feed content.