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We characterized a recombinant mosaic coxsackievirus A9 strain responsible for severe inflammatory cardiomyopathy in a previously healthy child in northeastern France in 2024 by using whole-genome sequencing. This case highlights that enterovirus species other than coxsackievirus strain B3 can cause cardiomyopathy in otherwise healthy pediatric patients.
Coxsackievirus strain A9 (CVA9) is a human pathogen classified within the species Enterovirus betacoxsackievirus (species B enterovirus [EV-B]). Infections linked to CVA9 show up in children, typically hand, foot, and mouth disease or episodes of aseptic meningitis ( 1 ).
Epidemiologic tracking points to CVA9 as a frequent nonpolio enterovirus found in patient samples worldwide ( 1 ). During a 5-year survey in Europe from 2018–2023, this virus appeared among the 10 most documented enterovirus strains in clinical samples ( 2 ).
CDC Emerging Infectious Diseases Journal published a clinical update in Infectious Disease on 10 Apr 2026.
The item focuses on Cardiomyopathy Caused by Coxsackievirus Strain A9 in Previously Healthy Child, Northeastern France, 2024.
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