Multidimensional Social Adversity and Mortality in People With HIV Infection and Heart Failure: Insights From NYC Health + Hospitals HIV–Heart Failure Cohort

19 May 20264 min read0 viewsJournal Feed

GIST (Key Takeaways)

Circulation, Volume 153, Issue 24 , Page 1903-1914, June 16, 2026. BACKGROUND:Heart failure is an increasingly common comorbidity among people with HIV infection, complicating care and heightening the vulnerability of this population to social adversity (SA).
However, the impact of different SA domains on outcomes in this population remains poorly understood. METHODS:We analyzed data on people with HIV infection and heart failure from the NYC 4H (NYC Health + Hospitals HIV–Heart Failure) cohort.
Baseline multidimensional SA was assessed by licensed clinical social workers using standardized evaluations and grouped into 5 domains: economic hardship, health care access barriers, neighborhood or built environment instability, social support challenge, and psychobehavioral instability. We used multivariable adjusted Cox models to estimate hazard ratios (HRs) of all-cause, cardiovascular, and infection-related mortality and logistic regression to estimate odds ratios of 6-month rehospitalization risk.
RESULTS:Among 1044 participants (62.9% male; mean age, 61.6 years), 601 (58%) reported at least 1 SA: economic hardship (n=130), limited health care access (n=155), unstable housing (n=129), social support challenge (n=179), or psychobehavioral instability (n=438).

Clinical Editorial

Summary

Circulation published a clinical update in Cardiology on 19 May 2026.

The item focuses on Multidimensional Social Adversity and Mortality in People With HIV Infection and Heart Failure: Insights From NYC Health + Hospitals HIV–Heart Failure Cohort.

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