Official title: Medical Treatment With or Without Transcatheter Patent Foramen Ovale CloSure for Older Patients With CrypTogenic StrOke and Patent Foramen Ovale. The STOP Trial Summary: Patent foramen ovale PFO closure has been shown to reduce the risk of stroke in patients with recurrent stroke.
However, the majority of existing clinical studies in this field excluded patients over the age of 60 years. Data in older patients is limited and since the population ages and stroke remains a major cause of death and morbidity, randomized clinical trials are needed to better assess the benefit of PFO closure in this elderly population.
Therefore, this study proposal sought to determine the efficacy of PFO closure for the prevention of recurrent stroke in older patients with PFO and cryptogenic stroke. Conditions: Patent Foramen Ovale, Cryptogenic Stroke, Older Patients, Medical Treatment, Recurrent Stroke Study type: INTERVENTIONAL Primary purpose: TREATMENT Phases: NA Enrollment: 714 (ESTIMATED) Status: RECRUITING Completion: 2037-10-01 (ESTIMATED)
ClinicalTrials.gov published a clinical update in Cardiology on 27 Mar 2026.
The item focuses on Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure.
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