This study aims to structurally and microbiologically characterize biofilms on arterial catheters in ICU patients using optical coherence tomography (OCT). The investigators note that bacteremias in the ICU are frequently linked to vascular devices, with arterial catheters accounting for a portion of these infections and contributing to morbidity and mortality.
They state that biofilm formation on the inner surfaces of vascular devices is recognized, but there is a lack of clinical data establishing a causal relationship between biofilms and bacteremia. The project hypothesizes that improved structural and microbiological profiling of arterial catheter biofilms could aid in preventing bacteremias or enable more targeted management when infection occurs.
Key elements include an observational study design with an estimated enrollment of 60 participants and a recruiting status, with an anticipated completion in December 2027. The study employs OCT to assess biofilm structure and integrates microbiological analysis, within conditions specified as biofilms, arterial catheterization, peripheral devices, bacteremia, tomography, and optical coherence.
Evidence linking biofilm structure to bacteremia is described as lacking clinical data.