This work is titled "QT Prolongation, Ventricular Arrhythmia, and Cardiac Arrest Signals During Ceftriaxone Co-therapy with Individual Proton Pump Inhibitors: A Multidatabase Study" and is published in Cardiovascular Toxicology (Cardiovasc Toxicol). The PubMed entry lists the publication date as 2026 Sep 6; volume 26(10):103. The article is indexed with PMID 42701947 and DOI 10.1007/s12012-026-10174-z.
The title indicates the study is a signal detection investigation focused on cardiac safety endpoints during co‑therapy of ceftriaxone with individual proton pump inhibitors (PPIs). The PubMed record classifies the report as a Multicenter Study.
Authors named in the PubMed entry include Yechao Chen, Qiaoling Gu, Mingnuo Zhao, Aijin Zhao, Zirui Kong, Haobin Shen, Yanan Zhang, Shuang Wang, Li Li, Han Xie, Peipei Liu, Haixia Zhang, and Dayu Chen among others. Several authors are marked as having contributed equally.
Affiliations provided on the PubMed page are primarily academic and hospital pharmacy departments in China, including: Department of Pharmacy, School of Basic Medicine and Clinical Pharmacy, Nanjing Drum Tower Hospital, China Pharmaceutical University; Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University; Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine; and the First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi. Contact email addresses for some corresponding authors are listed in the affiliation block on PubMed.
Based on the title and indexing on PubMed, the study investigates potential pharmacovigilance signals for three cardiac safety outcomes associated with the concurrent use of ceftriaxone and individual proton pump inhibitors:
The study purports to evaluate these safety signals across multiple databases, which implies a large-scale, observational signal-detection approach rather than a single-center randomized trial. However, specific details about which databases were queried are not present in the PubMed page extract.
The article is described as a Multicenter Study and the title explicitly states a "Multidatabase Study." This indicates the authors used more than one pharmacovigilance or healthcare dataset to search for disproportionality or other signal metrics related to the drug combination and specified cardiac outcomes. The PubMed entry does not include the abstract text or the methodological specifics (for example, inclusion criteria, case definitions, comparator groups, statistical methods for signal detection, or adjustment for confounders).
The PubMed entry provides comprehensive bibliographic metadata (title, authors, affiliations, journal, publication date, PMID, DOI) but does not include the study abstract or quantitative findings in the captured page content. Specifically, the following were not reported in the accessible source content and therefore cannot be summarized here:
Because these key methodological and result details are absent from the PubMed extract, readers should not infer effect sizes, risk estimates, or clinical implications solely from the bibliographic entry.
The title highlights potential safety signals for serious cardiac outcomes with concomitant ceftriaxone and PPI therapy. Such signals warrant clinical attention and further evaluation, but the PubMed record alone does not supply the evidence needed to guide practice changes. Clinicians and researchers interested in the study should retrieve the full text (journal website or publisher link using the DOI) to review the methods, datasets, results, and the authors' interpretations before drawing conclusions or altering prescribing behavior.
The PubMed page includes standard navigational and affiliation details and indicates correspondence email addresses for some authors within the affiliation list. The PubMed extract provided does not show the conflict of interest statement, funding sources, or acknowledgments sections; those items typically appear in the full text and should be consulted directly in the published article.
Summary note
This PubMed entry provides validated indexing and author/affiliation metadata for a multicenter, multidatabase signal-detection study of QT prolongation, ventricular arrhythmia, and cardiac arrest during co‑therapy of ceftriaxone with individual proton pump inhibitors, but the abstract and study data are not available in the captured page content. For complete methodological details, numeric results, and the authors' conclusions, the full published article must be consulted.