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What We Learn From a Negative Randomised Controlled Trial in Bronchiolitis Obliterans Syndrome A

Overview of lung transplantation and chronic lung allograft dysfunction, focusing on bronchiolitis obliterans syndrome and its historical definition by ISHLT in 1993.

GIST

Extract Lung transplantation (LTx) is now a widely accepted procedure for end-stage pulmonary diseases. Nevertheless, long-term survival after LTx remains limited because of chronic lung allograft dysfunction (CLAD), which is mainly manifested as bronchiolitis obliterans syndrome (BOS), accounting for approximately 80% of CLAD cases [1]. The definition of BOS was first introduced in 1993 by an ad hoc working group of the International Society of Heart and Lung Transplantation (ISHLT), with the aim of developing a clinically applicable and standardised method for assessing functional results after LTx [2].

Clinical Editorial

European Respiratory Journal published a clinical update in Critical Care on 02 Apr 2026. The item focuses on What can we learn from a negative randomised controlled trial in bronchiolitis obliterans syndrome after lung transplantation?. Review the original article for the full source wording and details.

Original source: http://erj.ersjournals.com/cgi/content/short/67/4/2502412?rss=1