IntroductionIndividuals with Sjögren's syndrome (SjD) experience notable health challenges, including chronic pain, fatigue, and depression; however, the potential benefits of physical activity in alleviating these issues remain unclear. We aim to systematically assess the comprehensive effects of physical activity on individuals with SjD.MethodsA comprehensive literature search was conducted in Medline, Embase, Scopus, Web of Science, Cochrane Library, SPORTDiscus, and ClinicalTrials.gov for studies published from inception to November 2025.
Two independent reviewers screened the search results and extracted the data. Effect sizes were calculated as the standardized mean difference (SMDs) with 95% confidence intervals (CIs) using random-effects models.
Methodological quality was assessed using the Cochrane Collaboration Risk of Bias Tool 2.0, and the certainty of evidence was evaluated with the GRADEpro online tool. Sensitivity, subgroup, and regression analyses were performed to explore potential sources of heterogeneity.ResultsThis analysis included six studies with a total of 277 participants with SjD.
Frontiers in Immunology published a clinical update in Infectious Disease on 07 Apr 2026.
The item focuses on Effects of physical activity on health-related outcomes in Sjögren’s syndrome: a systematic review and meta-analysis of randomized controlled trials.
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