BackgroundHIV and hepatitis B virus (HBV) co-infection remains a major global health challenge and is characterized by profound immune dysregulation, including chronic immune activation, impaired antiviral immunity, and immune-mediated liver injury. With the widespread use of effective antiretroviral therapy, people living with HIV now experience prolonged survival, shifting clinical and research priorities toward long-term immunological consequences and chronic comorbidities such as HBV.
Although a rapidly expanding body of literature has explored HIV/HBV co-infection, a comprehensive immunology-oriented overview of global research trends, collaborative structures, and evolving immune-related research themes is still lacking.MethodsPublications related to HIV/HBV co-infection published between 2014 and 2024 were retrieved from the Web of Science Core Collection and Scopus databases. After data cleaning and deduplication, 1,649 eligible records were included.
Frontiers in Immunology published a clinical update in Infectious Disease on 14 May 2026.
The item focuses on Immunological research landscapes and emerging immune mechanisms in HIV/HBV co-infection: a bibliometric analysis (2014–2024).
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