Osteoporosis (OP) is a chronic metabolic bone disease characterised by low bone mass and deterioration of bone microarchitecture as its core pathological features, which predominantly affects the elderly population and postmenopausal women. Macrophages, as key components of the immune system, function in regulating inflammatory responses, tissue repair and immune modulation, and play a pivotal role in the pathogenesis and progression of osteoporosis: their distinct polarisation states can directly influence osteoblast differentiation and bone resorption activity, and the regulation of bone metabolic homeostasis mediated by macrophages has become one of the current research hotspots.
Frontiers in Immunology published a clinical update in Infectious Disease on 20 May 2026.
The item focuses on The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation.
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