Inflammation is a crucial regulator of body’s defense mechanism primarily modulated by the immune system. Context dependent immune activation (e.g., pathogen) requires acute inflammatory reactions followed by efficient resolution of inflammation.
Impaired resolution may lead to chronic inflammation, often associated with several pathological processes, including dementia disorders. At present, the mechanisms of inflammation resolution are poorly understood.
High levels of the neurotrophin nerve growth factor (NGF) are evident at the site of inflammation, however the effect of NGF on immune cells is debated, ranging from proinflammatory to anti-inflammatory. Thus, identifying the immune cells which possess NGF responsive receptors is crucial to understand how NGF can modulate immune function of those specific immune cells.
Utilizing multi-color flow cytometry, we mapped across various immune cell subtypes including adaptive and innate immunity landscape from unchallenged mouse spleen for the presence of NGF receptors (TrkA and p75).
Frontiers in Immunology published a clinical update in Infectious Disease on 23 Apr 2026.
The item focuses on Nerve growth factor responsive elements modulate immune cell inflammation and are dysregulated in an Alzheimer’s disease mouse model.
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