Arachidonate 15-lipoxygenase (ALOX15) is a lipoxygenase that oxidizes polyunsaturated fatty acids to yield a range of lipid mediators with biologic activity. In inflammation, ALOX15-derived products participate in both resolving inflammation and propagating inflammatory signaling, producing pro-resolving mediators as well as pro-inflammatory lipid signals that can amplify tissue damage.
Animal models with gene knockout or transgenic manipulation indicate that ALOX15 contributes to disease processes in several inflammation-related conditions. Evidence links ALOX15 to neuroinflammatory processes, atherosclerotic development, asthma, rheumatoid arthritis, and metabolic inflammatory disorders, suggesting a multifaceted involvement in pathogenesis rather than a single directional effect.
The overall picture is that ALOX15 has context-dependent roles, supporting resolution in some settings while promoting inflammation in others, which may influence disease progression and severity. The article provides a systematic synthesis of current findings on ALOX15’s contributions across inflammation-associated diseases, highlighting both its regulatory complexity and potential as a therapeutic target.
Uncertainty remains regarding the precise conditions under which ALOX15 shifts toward pro- vs pro-resolving pathways in specific diseases.
Frontiers in Immunology published a clinical update in Infectious Disease on 02 Apr 2026.
The item focuses on The role of ALOX15 in inflammation-related diseases.
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