From Autoimmunity to intestinal Tissue Damage: Insights From Potential Celiac Disease as a Parad

Immune-mediated inflammatory diseases are undergoing a paradigm shift from treatment of established pathology toward prevention in at-risk individuals. Celiac disease (CeD), driven by an aberrant immune response to dietary gluten in genetically predisposed subjects, represents an ideal model to investigate the transition from tolerance to autoimmunity. Within this framework, potential celiac disease (PCD)—defined by CeD-specific autoantibodies in the absence of villous atrophy—has emerged as a clinically relevant condition whose natural history, heterogeneity, and predictors of progression are increasingly understood.