Liver biochemical and function tests—alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, prothrombin time, and albumin—are used to screen and identify people with acute and chronic liver disease. Elevations in alanine aminotransferase and aspartate aminotransferase reflect hepatocellular injury, with more urgent evaluation required when the international normalized ratio of prothrombin is prolonged and the bilirubin level elevated. An elevation in alkaline phosphatase reflects a cholestatic process and impaired bile flow.
Gastroenterology (AGA) published a clinical update in Research Highlights on 12 Mar 2026.
The item focuses on Evaluation of Abnormal Liver Biochemical Test Results.
Review the original article for the full source wording and details.