We read with interest the article by de Frutos Rosa et al,1 comparing endoscopic submucosal dissection (ESD) vs transanal minimally invasive surgery (TAMIS) for early rectal neoplasms. Although the authors conclude noninferiority of ESD to TAMIS, we have several methodologic concerns.
Gastroenterology (AGA) published a clinical update in Research Highlights on 28 Feb 2026.
The item focuses on “Margin for Error”?
Reassessing Noninferiority in the DSETAMIS Trial.
Review the original article for the full source wording and details.