Hepatic congestion activates the yes-associated protein–connective tissue growth factor axis in liver sinusoidal endothelial cells through integrin αV, leading to liver fibrosis, portal hypertension, and liver carcinogenesis.
Gastroenterology (AGA) published a clinical update in Research Highlights on 27 Feb 2026.
The item focuses on Activation of the Integrin αV-YAP-CTGF Axis in Liver Sinusoidal Endothelial Cells Promotes Liver Fibrogenesis, Leading to Portal Hypertension and Liver Carcinogenesis in Congestive Hepatopathy.
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