Our work reveals the plasticity of pancreatic ductal adenocarcinoma tumor cell states and their interactions with the tumor microenvironment during chemotherapy, highlighting CD276/B7-H3 as a key regulator and promising therapeutic target for overcoming chemotherapy resistance.
Gastroenterology (AGA) published a clinical update in Research Highlights on 17 Feb 2026.
The item focuses on Single-Cell Analysis of Chemotherapy-induced Remodeling Reveals CD276-driven Basal-like Chemoresistance in Pancreatic Cancer.
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