Irritable bowel syndrome (IBS) is defined by symptoms of recurrent abdominal pain related to defecation and is categorized into the following 4 subgroups: IBS with predominant constipation (IBS-C), diarrhea (IBS-D), mixed (IBS-M), and unsubtyped. Despite its widespread impact, the pathophysiology of IBS remains elusive. A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) has been recognized as an effective dietary intervention for the reduction of gastrointestinal symptoms.
Gastroenterology (AGA) published a clinical update in Research Highlights on 11 Feb 2026.
The item focuses on Involvement of Eosinophil-Driven Intestinal Immune Activation in Different Irritable Bowel Syndrome Subtypes and in the Response to a FODMAP Lowering Diet: A Post Hoc Analysis of the Randomized Controlled DOMINO Trial.
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