Our work reveals the plasticity of pancreatic ductal adenocarcinoma tumor cell states and their interactions with the tumor microenvironment during chemotherapy, highlighting CD276/B7-H3 as a key regulator and promising therapeutic target for overcoming chemotherapy resistance.
Our work reveals the plasticity of pancreatic ductal adenocarcinoma tumor cell states and their interactions with the tumor microenvironment during chemotherapy, highlighting CD276/B7-H3 as a key regulator and promising therapeutic target for overcoming chemotherapy resistance.