Can Transperineal Ultrasound Replace Endoscopic Ultrasound in Ulcerative Colitis Staging?

In more detail Study approach The TRINITY study was a prospective diagnostic accuracy trial conducted at the Asian Institute of Gastroenterology (Hyderabad, India), comparing triple rectal ultrasound imaging technology: transabdominal ultrasound (TAS) and transperineal ultrasound (TPUS) with endoscopic ultrasound (EUS) as the reference standard for assessing rectal inflammation in ulcerative colitis (UC). The study was registered prospectively (NCT06717906).

Patients or the public were not involved in the design, conduct, reporting or dissemination of this research. Patient inclusion and exclusion Consecutively enrolled patients were aged 18 - 75 years with a diagnosis of UC ≥6 months.

Inclusion criteria were active disease (Simple Clinical Colitis Activity Index (SCCAI)>2) or clinical remission (≤2). Exclusion criteria included pregnancy, refusal of EUS or inability to undergo sigmoidoscopy.

Patient characteristics A total of 142 patients were included (median age: 40 years; 33.8% female; median body mass index (BMI): 22.5 kg/m²). Disease extent was proctitis (12%),...