This entry describes a letter titled Doxycycline Resistance and 16S rRNA Mutations in Treponema pallidum published in Emerging Infectious Diseases (Emerg Infect Dis) in August 2026 (volume 32, issue 8, pages 1384–1385). The PubMed record lists DOI 10.3201/eid3208.260433 and PMID 42521605. The PubMed page offers a CDC–NCEZID full-text link via the DOI.
The PubMed entry classifies the piece as a Letter. No abstract is provided in the PubMed record (the page explicitly states: "No abstract available"). As presented on PubMed, the record does not include the letter’s full text content, methods, data, or conclusions; those must be consulted in the linked full text source.
Authors listed on the PubMed record are Mathew A Beale, Michael Marks, Annie Luetkemeyer, Connie Celum, Matthew R Golden, Lorenzo Giacani, and Nicole A P Lieberman. The unique identifiers provided on the PubMed page are:
These identifiers should be used to retrieve the full text or to cite the letter in bibliographies and surveillance reports.
PubMed lists the following keywords for the record: Treponema pallidum; antimicrobial resistance; bacteria; syphilis. The article title further emphasizes doxycycline resistance and 16S rRNA mutations in Treponema pallidum, indicating the letter addresses genetic changes in the pathogen that relate to resistance to doxycycline.
The PubMed entry includes a full-text link to CDC–NCEZID (via the DOI). The PubMed record itself does not include the letter’s content or data; readers and clinicians should follow the DOI/full-text link to review the complete letter for experimental details, genetic findings, geographic or temporal context, and authors’ interpretations.
PubMed’s similar-articles section lists related studies and surveillance reports on Treponema pallidum molecular subtyping and antibiotic resistance surveillance. Examples shown on the PubMed page include molecular surveillance and resistance gene analyses from various settings, reflecting an active literature on antimicrobial resistance in T. pallidum. The specific contents and data of this 2026 letter, however, are not summarized on the PubMed record.
Because the PubMed entry contains no abstract and the letter text is not reproduced on the PubMed page, the following details are not reported in this record and therefore cannot be restated here:
Readers should consult the linked full text to obtain these primary details.
The title and keywords indicate the letter concerns the emergence or detection of doxycycline resistance associated with 16S rRNA mutations in Treponema pallidum, a topic of clinical and public health relevance for syphilis management and antimicrobial surveillance. However, because the PubMed record does not provide the letter’s content, no specific clinical guidance, prevalence estimates, or laboratory findings can be extracted from this source page alone.
To evaluate the evidence and implications, clinicians, microbiologists, and public health practitioners should review the full text via the provided DOI/CDC–NCEZID link and examine any primary data, methods, and authors’ interpretations presented in the letter.
References
(Primary bibliographic information taken from the PubMed record for PMID 42521605. No abstract or internal content was available on PubMed; further details require consulting the full text.)