Global Patterns of Mutational Profiles in Biliary Tract Cancer

Biliary tract cancers (BTCs) are a group of rare but highly lethal cancers that include intrahepatic cholangiocarcinoma (iCCA), extrahepatic cholangiocarcinoma (eCCA), and gallbladder carcinoma (GBC). A major source of difficulties in modeling and treating these cancers is that their mutational landscapes exhibit extensive heterogeneity both within and across subtypes – extending to geographic and etiological differences – necessitating large cohorts to achieve robust statistical assessment. Here, we collate and analyze data from over 30 next generation sequencing studies to provide a comprehensive overview of BTC mutational patterns and their potential clinical implications.