Most Pediatric hepatocellular tumors are classified as hepatoblastoma (HB) or hepatocellular carcinoma (HCC), yet a subset exhibits mixed histological and molecular features. These hepatoblastomas with carcinoma features (HBCs) include cases provisionally designated as hepatocellular neoplasm–not otherwise specified (HCN-NOS).
Their biology remains poorly understood, with unresolved questions about their cellular composition and outcomes. It is unclear whether HBCs comprise hybrid cell populations with combined HB and HCC characteristics (HBC cells) or admixtures of distinct HB and HCC cells.
Journal of Hepatology published a clinical update in Research Highlights on 28 Feb 2026.
The item focuses on Asynchronous Transitions from High-Risk Hepatoblastoma to Carcinoma.
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