Kupffer cells (KCs), the prenatally seeded macrophages of the liver, show unique functional and immunophenotypic features among tissue-resident macrophages. They are considered as terminally differentiated with negligible cellular postnatal input.
Their adaptability in disease is attributed to recruited, monocyte-derived KCs. Here, we explored KC plasticity and the impact of their ontogeny in persisting mycobacterial infections, which primarily target macrophages.
Journal of Hepatology published a clinical update in Research Highlights on 04 Mar 2026.
The item focuses on Kupffer cell plasticity regulates hepatic immunity in mycobacterial infection.
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