We read with great interest the mechanistic study comparing short-term hypocaloric ketogenic versus non-ketogenic diets in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD), which integrated proton magnetic resonance spectroscopy-quantified intrahepatic triglyceride (IHTG) with isotope tracer-based flux phenotyping and targeted plasma metabolomics [1]. The authors reported greater relative reductions in IHTG with the ketogenic diet compared with the non-ketogenic diet, accompanied by larger decreases in the homeostasis model assessment of insulin resistance (HOMA-IR).
Journal of Hepatology published a clinical update in Research Highlights on 18 Feb 2026.
The item focuses on Ketogenic diets in MASLD: methodological limitations and the confounding role of protein intake.
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