Approaching the Holy Grail in Autoimmunity: CD19 CAR T-Cell Therapy in Multiorgan IgG4-Related D

IgG4-related disease (IgG4-RD) is a chronic, fibroinflammatory disorder defined by IgG4-rich lymphoplasmacytic, pseudotumoral infiltrates.1 Its pathogenesis – shaped by genetic susceptibility and (auto-)antigenic or environmental triggers – reflects dysregulated crosstalk between B cells/plasma cells and specialized T-cell subsets.1 The resulting immune cascade can cause aggressive inflammation and organ damage across any tissue, most commonly the pancreas, biliary tract, salivary glands, kidneys, and lungs.