Journal of the American Heart Association, Volume 15, Issue 9 , May 5, 2026. BackgroundCoronary heart disease (CHD) has been established as a risk factor for stroke.
The study aimed to assess how age at CHD onset influences stroke risk and interacts with genetic predisposition to stroke.MethodsThis prospective cohort study included UK Biobank participants without baseline or pre‐CHD stroke. Polygenic risk scores assessed genetic susceptibility.
Cox models and propensity score matching investigated the association between CHD onset age and stroke. The interaction analysis was performed using the bootstrap method and likelihood tests.
Sensitivity analyses were conducted to ensure robustness.ResultsOver a median follow‐up of 15.1 years, 11 180 participants experienced incident stroke. Patients with CHD exhibited higher risks of developing stroke, hemorrhagic stroke, and ischemic stroke than participants without CHD.
Notably, each 10‐year decrease in onset age correlated with an increased risk of stroke (hazard ratio [HR], 1.27 [95% CI, 1.23–1.32];P<0.001), hemorrhagic stroke (HR, 1.31 [95% CI, 1.20–1.43];P<0.001), and ischemic stroke (HR, 1.28 [95% CI, 1.23–1.33];P<0.001).
Journal of the American Heart Association published a clinical update in Cardiology on 22 Apr 2026.
The item focuses on Age at Coronary Heart Disease Onset, Genetic Susceptibility, and Subsequent Risk of Stroke.
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