Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. BackgroundObstructive hypertrophic cardiomyopathy (oHCM) is associated with adverse clinical outcomes.
This study aimed to evaluate real‐world clinical outcomes, health care resource use, and health care costs in patients with oHCM stratified by their sociodemographic characteristics.MethodsThis retrospective, noninterventional cohort study from the Optum Market Clarity Integrated Clinical and Claims database included US adults with ≥2 medical claims with a diagnosis code for oHCM (2013–2021). Dependent on outcome measure, follow‐up was variable, fixed 1‐year, or fixed 5‐year.
Outcome measures were rate of major adverse cardiovascular events, medication use, HCRU, and health care costs.ResultsThe study included 14 744 patients with oHCM (mean±SD age, 61.8 [14.0] years; 7504 [50.9%] female). Female patients had a higher rate of stroke than male patients (6863 versus 4773 per 100 000 patient‐years), and Black patients had a higher rate of heart failure than White patients (31 084 versus 20 603).
Patients in the South had a higher rate of heart failure than patients in the Northeast (25 406 versus 18 705).
Journal of the American Heart Association published a clinical update in Cardiology on 27 Feb 2026.
The item focuses on Impact of Sociodemographic Characteristics on Outcomes in Obstructive Hypertrophic Cardiomyopathy.
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