Journal of the American Heart Association, Volume 15, Issue 9 , May 5, 2026. BackgroundGrip strength and walking pace are potential indicators of adverse health outcomes for the general population.
However, their role in primary cardiovascular disease (CVD)prevention among various subpopulations remains uncertain.MethodsA total of 206 371 individuals withoutCVD(aged 40–69 years) fromthe UK Biobankwere included. Four conventionalCVDprediction models (Framingham, Reynolds, ASSessing cardiovascular risk using Scottish Intercollegiate Guidelines Network [ASSIGN], andpooled cohort equations [PCEs]) were used to estimate 10‐yearCVDrisk.
Model performances were compared across diverse subpopulations defined by age, grip strength, or walking pace using a C index and calibration plot inthe UK Biobank. Added predictive value was further validated inELSA (English Longitudinal Study of Ageing).ResultsDuring the follow‐up period 19 664 cases of incidentCVDwere registered (mean 12.85 years [SD2.74]).
Vulnerable subpopulations were characterized by advanced age, low grip strength, or slow walking pace.
Journal of the American Heart Association published a clinical update in Cardiology on 28 Apr 2026.
The item focuses on Walking Pace Optimizes Conventional Cardiovascular Disease Risk Prediction Models Among Vulnerable Subpopulations: A Prospective Cohort Study.
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