Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. BackgroundStudies have demonstrated an association between endothelial dysfunction and major depressive disorder (MDD).
However, the link between coronary endothelial dysfunction (CED) and an incident diagnosis of MDD across sexes is unclear.MethodsPatients with nonobstructive coronary artery disease (stenosis <40%) underwent an invasive assessment of CED. Macrovascular CED was defined as a percentage change in coronary diameter in response to acetylcholine of ≤−10% compared with baseline.
Microvascular CED was defined as a percentage change in coronary blood flow in response to acetylcholine of ≤−50% compared with baseline. In the period after the index procedure, patients were followed up for developing a diagnosis of MDD, and logistic regression was performed to assess the association between baseline CED and incident MDD.ResultsIn total, 2280 patients underwent invasive testing for CED.
A total of 516 patients (23%) underwent an evaluation for MDD at a dateafterthe index procedure (mean±SD age, 53±12 years; 72% women). A total of 160 (31%) were diagnosed with MDD.
Journal of the American Heart Association published a clinical update in Cardiology on 13 Mar 2026.
The item focuses on Coronary Endothelial Dysfunction Is Associated With Major Depressive Disorder in Men With Chest Pain and Nonobstructive Coronary Artery Disease.
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