Journal of the American Heart Association, Volume 15, Issue 6 , March 17, 2026. BackgroundAlthough current cardiopulmonary resuscitation guidelines recommend administering epinephrine at 3‐ to 5‐minute intervals during advanced life support (ALS), scientific evidence for the optimal dosing interval for enhancing hemodynamic parameters remains limited.
Therefore, we compared the hemodynamic effects of 1‐, 3‐, and 5‐minute epinephrine dosing intervals on blood pressure augmentation in a porcine ventricular fibrillation cardiac arrest model.MethodsForty‐two pigs were randomly assigned to 1‐, 3‐, and 5‐minute epinephrine dosing‐interval groups. After ventricular fibrillation induction and a 2‐minute downtime, basic life support was initiated with a 30:2 compression‐to‐ventilation ratio for 8 minutes, followed by 30 minutes of ALS, including asynchronous ventilation at a rate of a single ventilation every 6 seconds, with oxygen delivered at 15 L/min.
Epinephrine (0.02 mg/kg) was administered at predetermined intervals of 1, 3, or 5 minutes.
Journal of the American Heart Association published a clinical update in Cardiology on 04 Mar 2026.
The item focuses on Comparison of the Hemodynamic Effects of Epinephrine on Blood Pressure Augmentation at 1‐, 3‐, and 5‐Minute Dosing Intervals.
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